Calvert Holdings

Calvert Holdings provides vision, resources, and business leadership for all of the companies it develops and acquires. Life sciences are a core competency, but not all our business endeavors are within that field. Click the links to explore our companies, or contact us for more information.
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Other Calvert Companies

Discovery Pharmacology

  • Leader in discovery pharmacology since 1969
  • Over 150 standard pharmacology models
  • Specialists in developing customized models
  • Broad screening projects
  • Covers all body functions/organ systems
  • Specific mechanistic studies

Programs are in place in a wide range of therapeutic areas to identify/optimize leads or resolve specific mechanistic questions. Clients can select from well over one hundred standard pharmacology models, or work with us to develop a customized model. We are accustomed to tailoring cost-effective strategies to identify and characterize your molecules quickly and thoroughly.

Diabetes Discovery Program
Under the banner of Discovery Pharmacology we offer in vivo models to screen and/or develop lead compounds in the field of Diabetes. Our Diabetes Discovery Program has lead to the development of lead compounds that were ultimately licensed by several of our clients.

Lead Optimization
Calvert’s Pharmacology Group can fully characterize lead compounds using specific animal models tailored to your compound’s intended clinical indication. Programs are in place in the areas of Cardiovascular, CNS, Inflammation/Analgesia, Metabolic Diseases, and Cancer. Models are available in all standard laboratory species including non-human primate. Calvert has a reputation for innovation by developing novel models and techniques to accommodate specific sponsor requests. Our seasoned pharmacologists can answer tough development questions.

Lead Identification
Using limited amounts of test article, Calvert can help determine initial in vivo activity or select the best lead from a series. For example, over two hundred compounds were run through db/db mouse diabetes model to select lead compounds from an in-house discovery program, resulting in the identification and successful partnering of several compounds.

New Model Development
Non-human primate behavioral assessments, telemetry, and respiratory measurements in conscious animals are but a few of the new models recently developed. Calvert can develop a novel model from published literature or from a specific client request. Cross specialty studies can be set up which draw upon many disciplines – i.e. classic pharmacology models with immunological or toxicokinetic components. New surgical models are constantly being developed. For example, we routinely utilize pre-cannulated animals for pharmacological evaluations of test articles.