Safety
Pharmacology studies are designed to test the potential adverse effects of a
compound. Calvert was the first CRO to provide safety pharmacology services
and is a leader in this specialized field. We can provide GLP or non-GLP
studies and offer a comprehensive series of tests covering the five major
organ systems (CNS, CV, GI, Renal, and Pulmonary) in support of existing
regulatory requirements and guidelines.
Clients
of Calvert respect our recommendations for Safety Pharmacology tests designed to satisfy worldwide regulatory agencies. Our Safety Pharmacology Packages have been duplicated by many industrial laboratories.
ICH S7A-Core Battery
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CNS study
(Modified Irwin) in Mice and Rats
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Cardiovascular Study in Dogs and
Monkeys (Anesthetized or Telemetry)
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Pulmonary
Assessment in Rats or Guinea Pigs
(Anesthetized or Conscious)
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ICH S7A-Supplemental
Study
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Renal Function Assay in Rats
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GI Propulsion Assay in Mice or Rats
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Barbiturate Sleep Time Potentiation in Mice
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Autonomic
function in isolated guinea-pig ileum
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Chemically
Induced Seizures in Mice
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Proconvulsant Activity (Sub MES Seizure Assay) in Mice
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Spontaneous
Motor Activity in Mice
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ICH S7B-QT
Prolongation
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Action
Potential in Purkinje Fiber
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QTc Assay
in Dogs, Guinea Pigs or Rabbits
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QT
Prolongation and Torsade de Pointes in Methoxamine-pre-treated Rabbits
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hERG Assay in
HEK 293 cells
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Having
spearheaded many innovations in the field, Calvert is recognized as a world
leader in Safety Pharmacology. Our pharmacologists have been invited to
chair sessions and serve as moderators at safety pharmacology meetings and symposiums in the USA and Europe.
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