Calvert
Laboratories has established a worldwide reputation as a leader
in pharmacology since 1969.
Our pharmacologists are respected scientists recognized
as industry leaders with the ability to customize lead development
strategies as well as replicate sponsor-derived methodologies.
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Discovery
Pharmacology
Calvert
offers services ranging from broad screening projects to specific mechanistic
studies. Select from many standard pharmacology models, or work with us to develop a customized model.
Calvert will tailor cost-effective strategies, which will characterize the pharmacological properties
of your molecules quickly and thoroughly.
With more than 30+ years of experience, Calvert has excelled in many fields of
Pharmacology. Most prominent, however, are the fields of
safety pharmacology, inflammation/ analgesia,
cardiovascular diseases and diabetes. Our discovery pharmacology programs in these fields
are renowned within the industry. Calvert offers an anti-inflammation/analgesia
program capable of an in vivo testing for COX1 , COX2 , PGE2 , PLA2 , and TNFa inhibitors.Safety
Pharmacology
Click HERE for comprehensive information.
Cardiovascular
Pharmacology
In the area of cardiovascular pharmacology, Calvert is capable of offering lead
development, customized protocol design and screening models of high
sophistication.
Our experienced cardiovascular pharmacologists have established a reputation as
leaders in customized protocol design which has led to the development of lead
compounds resulting in proven efficiency in early clinical evaluations.
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Hemodynamic
Evaluation. The
classic anesthetized dog preparation (hemodynamic evaluation) allows for better
control over measured parameters. Since this is one of the most frequently run safety
pharmacology studies at Calvert, you get the confidence of reliable and accurate data collection.
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Conscious,
Telemeterized Models allow test article effects to be evaluated without
interference or potential interaction with anesthesia. Telemetered studies are
performed in the rat using the DSI System, with evaluations on heart rate, blood
pressure, temperature, and Lead II ECG. The ITS telemetry system is used in the
dog and primate. Animals are monitored from a remote location, eliminating
artifacts induced by human handling, restraint, or tethers. With this system,
data can be collected continuously for days, weeks or even months. This allows
for a very thorough cardiovascular evaluation.
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QT
Prolongation Studies are becoming increasingly requested by regulatory
bodies throughout the world. In vivo dog and guinea pig models to assess
QT prolongation and our in vitro canine Purkinje fiber model to assess
prolongation of APD are available.
Lead
Identification
Using limited amounts of test article, Calvert can help determine initial in
vivo activity or select the best lead from a series. Our recommendations,
based on years of experience, help our clients make cost effective decisions
using sound pharmacological information.
Lead
Optimization
Fully
characterized lead compounds using specific animal models are tailored to your
compound's intended clinical indication. Calvert has a reputation for
innovation by developing novel models and evaluation techniques that accommodate
specific sponsor requests. Programs are in place in the areas of cardiovascular,
CNS, inflammation/analgesia, metabolic diseases and cancer.
New
Model Development
In
addition to well over 100 standard in vivo pharmacological models,
Calvert can work up a novel model from published literature or specific client
request.
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